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KMID : 0361020220650020079
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Korean Journal of Otolaryngology - Head and Neck Surgery
2022 Volume.65 No. 2 p.79 ~ p.85
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The Role of MicroRNA in Head and Neck Cancer
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Kim Yeon-Soo
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Abstract
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Head and neck squamous cell carcinoma (HNSCC) include epithelial tumors arising in thestructures of aerodigestive tract such as oral and nasal cavity, pharynx, larynx, paranasal sinuses,and local lymph nodes. HNSCC is the sixth most common cancer worldwide, and itsprognosis is very poor. MicroRNAs (miRNAs) are small single stranded noncoding RNAswhich are about 19-25 nucleotides involved in cell proliferation, development, differentiationand metastasis. It is believed that miRNA alterations correlate with initiation and progressionof cancer cell proliferation or inhibition of tumorigenesis especially in development, progression,and metastasis of HNSCC. Altered expression of miRNAs could be novel molecular biomarkersfor the diagnosis and prognosis of HNSCC. Despite the advances in cancer treatment,the mortality rate of HNSCC is still high. The potential application of miRNAs for cancertherapy has been demonstrated in many studies. In this review, we discuss the very recentstudies on different aspects of miRNA dysregulation with their clinical significance and miRNA-based therapy.
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KEYWORD
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Biomarker, Diagnosis, Head and neck cancer, Metastasis, miRNA.
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